Senior Manager, Commercialization FP&A

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: Revolution Medicines is seeking a Senior Manager, Commercialization FP&A to support our growing Global Commercialization organization. The Senior Manager, Commercialization FP&A will be a key operational finance partner across Global Commercial Development, US Commercialization, and Global Medical Affairs teams. This role reports to the Senior Director, Commercialization FP&A. Support Global Commercialization FP&A cadences including annual budget, quarterly forecasting, and long-range planning; partner with functional leaders to align assumptions, timing, and resource needs and utilize FP&A systems (Adaptive) for consolidation and reporting. Own and deliver executive-ready management reporting packages (budget vs. actuals, forecast updates, regional/product P&L views as applicable) and clearly communicate key insights, risks, and opportunities. Drive monthly variance analysis of actuals vs. budget/forecast; investigate discrepancies, understand key business drivers, and provide actionable recommendations to stakeholders. Provide ad hoc analytical support to enable decision-making, including spend tracking, benchmarking, and scenario analysis (e.g., resourcing trade-offs, vendor strategy, and investment prioritization). Lead the monthly accounting close process for Global Commercialization OPEX, including preparation of month-end OPEX accrual journal entries and review of open POs, invoices, and service completion status in coordination with Accounting/Procurement and functional operations teams. Establish and maintain governance for PO coding and mapping to ensure alignment to business initiatives, accurate initiative-level reporting, and scalable cost management practices. Maintain a continuous improvement mindset across processes, systems, and reporting—identifying opportunities to standardize, automate, and strengthen controls as Revolution Medicines scales into a global, fully integrated commercial-stage company. Required Skills, Experience and Education: Bachelor’s degree in Finance, Accounting, or related field. 6+ years’ experience in a similar role in biotechnology industry. Highly proficient in Excel, PowerPoint and AI automation (Codex, Claude Code). Experience working effectively in a demanding environment with minimal direction. Strong work ethic and ability to adjust workload based on changing priorities. Highest standards of accuracy, precision, and diligence; highly organized. Ability to think creatively, highly driven, and initiative-taking. Ability to work effectively and collaboratively cross-functionally with demonstrated ability to multi-task, prioritize options, anticipate challenges, and execute corporate goals. Strong analytical and advanced excel skills as well as excellent written and verbal communication skills. Preferred Skills: CPA or MBA preferred. Demonstrated experience utilizing financial systems and other business intelligence tools; NetSuite, Adaptive Insights (including OfficeConnect), and Coupa experience. #LI-Hybrid #LI-TS1 The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base…