Vice President, Clinical Development

Spyre Therapeutics is a clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients. Spyre's pipeline includes investigational extended half-life antibodies targeting α4β7, TL1A, and IL-23. Role Summary: The Vice President, Clinical Development (Immunology & Inflammation), reporting to the SVP of IBD Clinical Development, will provide strategic and operational leadership across Spyre's clinical portfolio of antibody therapeutics for IBD. This role is uniquely designed for a physician leader who thrives in a high-growth biotechnology environment and enjoys balancing long-term clinical development strategy with hands-on execution. The successful candidate will personally lead the ongoing Phase 2 platform study while helping to shape the future registrational program. Key Responsibilities: Clinical Leadership: Provide strategic leadership and medical expertise for the clinical development of our cutting-edge antibody portfolio in IBD. Develop and continuously refine integrated clinical development plans aligned with corporate objectives, competitive landscape, and evolving scientific insights. Serve as a hands-on study lead for the current platform trial as well as contribute to planning pivotal studies. Personally contribute to protocol development, medical review, safety assessment, data interpretation, and study-level decision making for ongoing and future IBD clinical trials. Support the efforts of the medical monitoring team which ensures timely responses to investigative sites, provides medical safety oversight, and supports the collection of high-quality, clinically robust data. Program Strategy & Trial Execution: Provide medical and scientific leadership for the design, conduct, analysis, and interpretation of clinical studies across all phases of development. Lead protocol development, study conduct, data review, and interpretation for ongoing clinical trials, partnering closely with clinical operations, regulatory, biometrics, etc., to ensure successful execution. Drive key development decisions through analysis of emerging clinical, translational, safety, and competitive data. Chair or contribute to governance committees and cross-functional program teams. Cross-functional Collaboration: Partner closely with Regulatory Affairs, Biostatistics, Clinical Operations, Translational Sciences, Medical Affairs, CMC, Commercial, and Corporate Development teams to ensure coordinated execution of development strategies. Promote a culture of scientific excellence, accountability, and collaboration. Regulatory Interface: Lead clinical and medical strategy for regulatory interactions globally. Serve as a primary medical representative for regulatory submissions, including INDs, CTAs, briefing packages, BLAs, NDAs, and related responses. Ensure development programs are conducted in compliance with global regulatory requirements and industry best practices. Safety Oversight: Provide ongoing medical oversight of participant safety and benefit-risk assessments across assigned programs. Review and interpret emerging safety data and contribute to safety governance activities, including Data Monitoring Committees and internal safety review forums. Support signal detection, risk management planning, and clinical risk mitigation strategies. Leadership & Mentorship: Lead and mentor a high-performing clinical development team as the company grows. Contribute broadly to corporate strategy, organizational planning, and leadership initiatives. Other duties as assigned. Ideal Candidate: MD or equivalent medical degree is required. Minimum of 7+ years clinical development experience within the pharmaceutical or biotech industry, including substantial leadership experience in immunology, inflammation, or gastroenterology. Training and/or experience in clinical development…