Sr. Principal Scientist

Legend Biotech is a global biotechnology company dedicated to treating and, one day, curing life-threatening diseases. Headquartered in Bridgewater, New Jersey, we are advancing the next generation of cell therapy through a portfolio of innovative technologies, including autologous, allogeneic, and in vivo cell therapy approaches. Our research spans chimeric antigen receptor T-cell (CAR-T), T-cell receptor (TCR-T), natural killer (NK) cell-based therapies, and other emerging platforms designed to transform the treatment of serious diseases. From our global network of research and development sites, we are committed to discovering and developing safe, effective, and cutting-edge therapies for patients worldwide. Legend Biotech entered into a global collaboration agreement with Johnson & Johnson to jointly develop and commercialize CARVYKTI® (ciltacabtagene autoleucel; cilta-cel). Through this strategic partnership, we combine complementary expertise and capabilities to advance innovative immunotherapies for patients living with multiple myeloma. Legend Biotech is seeking a Sr. Principal/Principal Scientist as part of the Research & Early Development team based in Somerset, NJ . Role Overview Legend Biotech is seeking a highly experienced Senior Principal Scientist / Principal Scientist – Flow Cytometry to provide scientific leadership and hands-on expertise in flow cytometry to support cell and gene therapy programs from IND-enabling studies through early- and late-stage clinical development. This role is critical for ensuring scientific rigor, data quality, and strategic insight across in-house and outsourced flow cytometry activities, including assay development, validation, CRO oversight, and deep data interpretation to support translational, PK/PD, and regulatory decision-making. Key Responsibilities Lead the design, development, optimization, qualification, and validation of multicolor and spectral flow cytometry assays supporting IND-enabling animal studies and clinical trials. Provide subject-matter expertise in panel design, antibody and reagent qualification, gating strategies, and data analysis for complex immunophenotyping applications. Conduct deep scientific review and interpretation of flow cytometry datasets to support PK/PD, mechanism-of-action, and translational insights. Serve as the primary scientific lead for external laboratories and CROs performing flow cytometry assays. Oversee assay transfer, validation, execution, troubleshooting, and data delivery at CROs. Ensure outsourced activities meet Legend quality standards, regulatory expectations, and program timelines. Identify risks related to assay performance, data quality, and operational execution, and implement mitigation strategies. Author, review, and approve bioanalytical assay validation reports, study reports, and regulatory documentation. Ensure flow cytometry assays and data packages are inspection-ready and compliant with GxP principles and data integrity requirements. Contribute to bioanalytical sections of IND and other regulatory submissions. Partner with Clinical, Translational Research, Biomarkers, Nonclinical Safety, and Data Science teams to align assay strategy with program objectives. Provide scientific input to study design, endpoint selection, and interpretation of bioanalytical results. Communicate complex data clearly to multidisciplinary stakeholders. Establish and maintain SOPs, best practices, and governance for in-house flow cytometry workflows. Mentor and scientifically guide junior scientists and associates. Evaluate and implement new technologies, platforms, and analytical approaches to enhance capabilities. Requirements Ph.D. in Immunology, Cell Biology, Molecular Biology, or related discipline with 8+ years (Principal Scientist) or 10+ years (Senior Principal Scientist) of relevant industry experience; or M.S. with 12+ years of experience. Extensive hands-on experience with multicolor and spectral flow cytometry platforms.…