Senior Vice President, Sales

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply. The Opportunity The SVP of Sales will play a critical leadership role in building and executing the commercial strategy for a pre‑commercial biotechnology company preparing for its first product launch. This individual will be responsible for designing and implementing the Go‑To‑Market (GTM) strategy, recruiting and developing a high‑performing sales organization, establishing strong relationships with Key Opinion Leaders (KOLs), ensuring full sales force readiness ahead of launch and driving performance. We anticipate hiring the Senior Vice President, Sales in September 2026. The ideal candidate combines strategic vision with hands‑on execution experience in specialty pharma or biotech launches and thrives in a fast‑paced, build‑from‑scratch environment. Responsibilities Enterprise Commercial Leadership Shape overall U.S. commercial strategy in partnership with the Chief Commercial Officer, including long-range planning beyond initial launch. Play a key role in portfolio planning and lifecycle strategy, including future indications and pipeline assets. Contribute to Board-level discussions on commercial readiness, launch strategy, and performance. Partner with Finance and Executive Leadership on revenue planning, scenario modeling, and investment decisions. Go‑To‑Market Strategy & Execution Design and implement a comprehensive Go‑To‑Market plan, aligned with brand strategy, market access, patient services, medical affairs, and marketing capabilities. Translate clinical value propositions into clear commercial messaging and field execution plans. Partner cross‑functionally with Marketing, Medical Affairs, Market Access, and Operations to ensure launch readiness. Define sales territory strategy, targeting, segmentation, and deployment models. Establish key performance indicators (KPIs), sales forecasting processes, and performance management frameworks. Sales Organization Build‑Out Recruit, hire, and onboard a high‑caliber field sales team, including regional leadership. Design and evolve a scalable sales organization architecture, with the ability to expand across multiple teams, regions, and future product lines. Develop a multi-year sales capability roadmap, including leadership bench building and succession planning. Build and lead second-line leadership (RSDs/Area Directors) as the organization scales. Develop and implement training programs to prepare the team for launch, including disease state education, product knowledge, and selling skills. Create a performance‑driven culture focused on accountability, collaboration, and continuous improvement. Launch Preparation & Excellence Lead all sales‑related launch readiness activities, ensuring the field team is fully prepared for pre-launch and launch execution. Oversee development and deployment of sales tools, CRM processes, call planning, incentive compensation and reporting infrastructure. Ensure compliance with all regulatory, legal, and ethical standards. KOL & External Engagement Engage with Key Opinion Leaders (KOLs) and other key stakeholders to support scientific exchange and commercial insight gathering. Partner with Medical Affairs to ensure appropriate,…