Senior Project Manager, Clinical Operations

The Position At Maze Therapeutics, we believe precision medicine has the power to transform the lives of patients with both common and rare diseases. As Sr. Project Manager, Clinical Operations, you will play a critical role in driving operational excellence across our growing Clinical Operations organization. This position combines portfolio-level project management with strategic operational initiatives, partnering closely with Clinical Operations Study Leads, Oversight Directors, and cross-functional teams to support the successful execution of multiple clinical pharmacology studies, early-phase studies, Phase 2 studies, and Phase 3 development programs, In this role, you will facilitate cross-functional planning and communication, coordinate complex study execution activities across the clinical portfolio, and oversee key Clinical Operations initiatives that strengthen organizational capabilities, improve processes, and drive operational excellence. As Maze continues to grow, you will partner with the Head of Clinical Operations to help establish scalable operational infrastructure, implement innovative technologies, and support initiatives that enable efficient, high-quality clinical trial execution across all stages of development. This role is ideal for a highly organized, collaborative project manager who enjoys bringing structure to complex initiatives, driving accountability, and enabling teams to deliver ambitious clinical development goals. The Impact You’ll Have Clinical Operations Project Management Partner with Clinical Operations Study Leads and Oversight Directors to coordinate project management activities across multiple Phase 1, clinical pharmacology, Phase 2, and Phase 3 studies, ensuring alignment of timelines, milestones, dependencies, and cross-functional deliverables. Develop and maintain integrated project plans, timelines, risk registers, and action trackers that support efficient study execution across the clinical portfolio. Monitor portfolio-wide study milestones, cross-study dependencies, operational risks, and key deliverables, proactively escalating issues and facilitating timely resolution. Coordinate cross-functional activities for Clinical Operations collaborating with Clinical Science, Biometrics, Data Management, Regulatory Affairs, Clinical Supply, Quality Assurance, and other functional teams. Develop project dashboards, status reports, and operational metrics that provide visibility into study execution, portfolio health, and organizational priorities. Cross-functional Leadership & Study Governance Partner with Clinical Operations Study Leads to coordinate, facilitate, and manage Study Execution Team (SET) meetings across multiple development programs. Develop meeting agendas, facilitate productive discussions, document decisions and action items, and drive accountability for follow-up activities. Coordinate governance meetings, operational reviews, leadership updates, and cross-functional planning sessions. Foster effective communication and collaboration across Clinical Operations, Clinical Science, Biometrics, Data Management, Regulatory Affairs, Clinical Supply, Quality Assurance, Finance, and other functional teams to ensure alignment on priorities and execution Strategic Clinical Operations Initiatives Oversee and coordinate cross-functional initiatives that strengthen Clinical Operations capabilities and improve organizational effectiveness. Manage implementation of strategic projects including: In-house eTMF implementation and governance Artificial intelligence (AI) initiatives Companion Diagnostic (CDx) operational workflows SOP development and revision working groups Inspection readiness initiatives Clinical Operations systems implementations (CTMS, eTMF, dashboards, etc.) Process improvement and organizational change initiatives Develop project plans, implementation strategies, communication plans, and timelines while tracking progress, risks, and dependencies. Support evalu…