Senior Manager, CMC Project Management

**About Allogene:** Allogene Therapeutics, with headquarters in South San Francisco, is a clinical-stage biotechnology company pioneering the development of allogeneic chimeric antigen receptor T cell (AlloCAR T) products for cancer and autoimmune disease. Led by a management team with significant experience in cell therapy, Allogene is developing a pipeline of “off-the-shelf” CAR T cell product candidates with the goal of delivering readily available cell therapy on-demand, more reliably, and at greater scale to more patients. **About the role:** We are looking for a talented, motivated Senior Manager to join our Portfolio & Program Management Team. This individual will serve as a key project management leader responsible for driving cross-functional planning and execution across one or more pipeline programs. The Senior Manager will partner closely with functional leaders across Operations Technology, Clinical, Regulatory, and other development functions to ensure disciplined planning, risk management, and delivery of program milestones. This role requires a strong foundation in project management with an emphasis on CMC knowledge and the ability to support Clinical Development activities as needed. The ideal candidate is a proactive, solutions-oriented leader who thrives in a fast-paced, highly collaborative environment and can translate program strategy into executable plans. This is a hybrid role based at our headquarters in South San Francisco, CA (US-based, west coast remote may be considered for candidates outside of the area). **Responsibilities include, but are not limited to:** - Lead cross-functional project teams or sub-teams to manage the planning and execution of program activities in alignment with corporate goals. Teams may include representatives from Process & Product Development, Manufacturing, Quality, Analytical Development, Supply Chain, Clinical Development, Clinical Operations, and Regulatory Affairs. - Develop, maintain, and actively manage integrated project plans including timelines, dependencies, critical path activities, decision points, and budget considerations. - Establish and maintain risk registries; proactively identify risks, define mitigation strategies, and escalate issues to prevent program delays. - Facilitate decision-making processes by working with cross-functional teams to develop proposals, analyses, and recommendations for senior management review as part of the governance process. - Serve as the primary project management point of contact for CMC and, as needed, Clinical Development activities on assigned programs. Ensure comprehensive knowledge of scope, deliverables, timelines, status, and key risks while coordinating cross-functional dependencies across CMC and Clinical workstreams to maintain alignment with program strategy. - Contribute to planning, organization, and preparation of regulatory filings (e.g., IND, BLA, CMC supplements) in partnership with Regulatory and relevant functional teams. - Prepare and deliver concise, data-driven program and project status updates, dashboards, and reports to senior leadership and governance forums. - Manage project team meeting operations including agenda planning, scheduling, minutes preparation, and follow-up on action items and decisions. - Ensure project activities and decisions are clearly communicated, documented, and archived in accordance with team standards and tools. - Foster strong relationships with team members, functional line managers, and external partners to facilitate timely resolution of issues, risks, and opportunities. - Support program-level budget management activities, including tracking expenditures and financial forecasting for assigned programs. - Participate as a member of the Portfolio & Program Management Team to continually improve project management processes, tools, and governance frameworks. - Other duties as assigned. **Position requirements & experience:** - Bachelor’s Degree in life sciences or re…