Senior Manager, Business Operations, G&A

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: This is an exciting opportunity to be a key member of the Business Operations – G&A team. Embedded within the Commercialization Effectiveness & Operations function, we partner across Global G&A and Commercialization-adjacent teams, including Finance, Legal, Human Resources, and Information Systems, Facilities, and Corporate Affairs. Our work brings together G&A operations and readiness, global commercialization contracts operations, change and capability enablement, as well as execution of prioritized cross-functional initiatives to strengthen organizational readiness, improve operational clarity, and support RevMed’s continued growth. The Senior Manager, Business Operations - G&A serves as a trusted business operations partner to G&A teams, enabling teams to execute against strategic priorities, foster cross-functional collaboration, and implement fit-for-purpose operational solutions. This individual brings strong project management, business operations, analytical and process improvement capabilities. They are comfortable evaluating complex business processes, identifying opportunities for optimization, translating business requirements into actionable solutions, and leveraging data and insights to support decision-making. Reporting to the Director, Business Operations – G&A, the ideal candidate is equally comfortable moving between planning, project execution, process improvement, data analysis, and stakeholder problem-solving, serving as both an operational project lead and analytical thought partner within an exciting, dynamic and fast-moving environment. Key Responsibilities: Partner with Business Operations - G&A team members and global G&A teams to plan, coordinate, and execute prioritized strategic and operational initiatives that support departmental and company priorities. Lead complex cross-functional projects, workstreams and working sessions, ensuring alignment on objectives, timelines, deliverables, dependencies, risks, mitigation plans, and success measures, ultimately driving project progress. Collaborate across Finance, Legal, Human Resources, Information Systems, Corporate Affairs, Facilities, Commercialization and other functions to drive alignment and execution. Support development of project charters, change management plans, stakeholder engagement strategies, and communications approaches. Lead change management activities for assigned initiatives, including stakeholder engagement, communications, adoption planning, and feedback loops. to support successful implementation of key initiatives. Develop business cases and project proposals, process analyses, operational metrics, reports/dashboards, and decision-ready insights and recommendations. Help design, document and operationalize processes, governance mechanisms, and operating rhythms for assigned initiatives and cross-functional workstreams. Create and maintain project documentation, including project charters, plans, timelines, status reports, process maps, meeting materials, and executive communications. Develop visual process documentation and operational tools to support business process design, continuous improvement, and cross-functional clarity. Partner with external consultants…