Senior/Executive Medical Director, Clinical Development (New Indications)

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients. Alumis is seeking an experienced Executive Medical Director or Senior Medical Director to lead clinical development strategy and execution for Phase 1 and Phase 2 studies in neurology and additional new indications. A centerpiece of this role is A-005, Alumis’s CNS-penetrant TYK2 inhibitor with potential in neuroinflammatory and neurodegenerative diseases — a first-mover opportunity to bring a differentiated mechanism to patients with devastating neurological conditions. This high-impact role will shape Alumis’s expanding clinical portfolio from the ground up, from indication selection and study design through proof-of-concept readout, and will serve as a key scientific leader and external face of the program with investigators, regulatory authorities, and the broader medical community. Key Responsibilities Clinical Development Strategy & Leadership Lead the design, planning, and execution of Phase 1 and Phase 2 clinical studies for A-005 in neurology (e.g., neurodegenerative diseases, movement disorders) and for additional pipeline molecules in inflammatory and immunologic indications Develop and refine clinical development plans, including study synopses, protocols, and integrated development strategies for new indications Provide clinical and scientific leadership to cross-functional study teams, ensuring alignment on program goals, timelines, and deliverables Collaborate with Translational Medicine and Research teams to evaluate and prioritize new indication opportunities based on scientific rationale, competitive landscape, and unmet medical need Study Execution & Oversight Serve as the Medical Monitor for assigned Phase 1 and 2 studies, ensuring patient safety and scientific integrity Oversee medical aspects of study conduct, including safety surveillance, protocol amendments, and data review Partner with Clinical Operations, Biostatistics, and Regulatory Affairs to ensure efficient study execution and high-quality data generation Lead interactions with Data Safety Monitoring Boards (DSMBs) and provide medical input for safety analyses Regulatory & External Engagement Contribute to regulatory strategy and serve as a clinical representative in interactions with FDA and international regulatory authorities (EMA, PMDA, etc.) Prepare and review clinical sections of regulatory submissions, including IND amendments, briefing documents, and meeting packages Represent Alumis at scientific conferences, advisory boards, and with Key Opinion Leaders (KOLs) to advance clinical programs and gather external insights Build and maintain relationships with investigators, academic collaborators, and the broader medical community Cross-Functional Collaboration Work closely with Translational Sciences, Biomarker, and Pharmacology teams to integrate biomarker strategies into clinical study designs Collaborate with Commercial and Medical Affairs teams on disease landscape assessments and indication prioritization Provide clinical expertise to support business development activities, including evaluation of potential partnerships or in-licensing opportunities Team Development Mentor and develop junior medical staff, fostering a culture of scientific excellence and collaboration Contribute to building Alumis's clinical development capabilities as the organization grows Required Qualifications MD required; neurology experience required; board certification or fellowship training in Neurology highly desired; additional experience in inflammatory disease areas (e.g., rheumatology, dermatology) a plus 10+ years of pharmaceutical/biotechnology industry experience in clinical development, with a significant focus on neurology; experience in im…