Senior Director, Clinical Development

Company Overview Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer. Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer. This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing. The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts. Summary The Senior Director, Clinical Development will provide medical and scientific leadership for Tango’s oncology development programs, driving clinical strategy from early-stage development through registration. Reporting to the President, Research & Development, this individual will lead cross-functional clinical teams, shape development plans, oversee study execution and medical monitoring, and serve as a key partner to investigators, regulators, and senior leadership. This highly visible role combines strategic leadership with hands-on clinical development responsibilities and offers the opportunity to directly influence the advancement of innovative precision oncology therapies for patients. The Senior Director will build and maintain strong relationships with investigators, key opinion leaders (KOLs), and external partners while ensuring the successful execution of clinical studies and overall program objectives. Your Role: Lead the clinical development strategy and execution for assigned clinical-stage oncology asset(s), partnering with cross-functional teams to create and implement comprehensive clinical development plans Provide leadership to the clinical team and serve as the medical and scientific expert for development programs Design, author, and oversee the development of study protocols, protocol amendments, investigator brochures, and other key clinical documents in compliance with project plans, global regulations, ICH/GCP guidelines, and Good Medical Practice Serve as the primary clinical lead for study investigators and key opinion leaders, building strong relationships that support program success and scientific advancement Lead clinical contributions to regulatory submissions, including INDs, CTAs, NDA/MAA filings, and interactions with Health Authorities Act as Medical Monitor and/or oversee external Medical Monitors for company-sponsored clinical trials, ensuring appropriate medical oversight and patient safety Provide strategic oversight of adverse event review, safety monitoring, protocol compliance, and clinical data evaluation Partner closely with Clinical Operations, Clinical Pharmacology, Biometrics, Regulatory Affairs, Drug Safety, Data Management, Quality, and Translational Sciences to ensure integrated and efficient execution of development programs Analyze and interpret clinical trial data and communicate findings through regulatory submissions, scientific publications, medical congress presentations, and internal governance reviews Lead responses to questions from Health Authorities, Ethics Committees, and Institutional Review Boards, ensuring consistency and scientific rigor Contribute to portfolio strategy, development planning, and broader organizational initiatives as needed Perform additional responsibilities as required to support the advancement of Tango’s clinical programs What You Bring: MD required; board certification or board eligibility in Medical Oncology, Hematology/Oncology, or a related specialty strongly preferred 5+ years of clinical development experience within the biotechnology and/or pharmaceutical industry, including experience leading oncology development programs Demonstrated experience in the design, execution, interpretation, and reporting of oncology clinical trials involvin…