Senior Director, Bioinformatics

About Summit: Summit Therapeutics Inc. is a biopharmaceutical oncology company with a mission focused on improving quality of life, increasing potential duration of life, and resolving serious unmet medical needs. At Summit, we believe in building a team of world class professionals who are passionate about this mission, and it is our people who drive this mission to reality. Summit’s core values include integrity, passion for excellence, purposeful urgency, collaboration, and our commitment to people. Our employees are truly the heart and soul of our culture, and they are invaluable in shaping our journey toward excellence. Summit’s team is inspired to touch and help change lives through Summit’s clinical studies in the field of oncology. Summit has multiple global Phase 3 clinical studies, including: Non-small Cell Lung Cancer (NSCLC) HARMONi: Phase 3 clinical study which was intended to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR-mutated, locally advanced or metastatic non-squamous NSCLC who were previously treated with a 3rd generation EGFR TKI. HARMONi-3: Phase 3 clinical study which is intended to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first-line metastatic NSCLC. HARMONi-7: Phase 3 clinical study which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first-line metastatic NSCLC. Colorectal Cancer (CRC) HARMONi-GI3: Phase 3 clinical study intended to evaluate ivonescimab in combination with chemotherapy compared with bevacizumab plus chemotherapy. Ivonescimab is an investigational therapy not presently approved by any regulatory authority other than China’s National Medical Products Administration (NMPA). Summit is headquartered in Miami, Florida, and has additional offices in California, New Jersey, the UK, and Ireland. Overview of Role: The Senior Director of Bioinformatics will provide scientific, strategic, and operational leadership for bioinformatics and computational biology activities supporting discovery, translational research, clinical development, and biomarker programs. This individual will work with a multidisciplinary team responsible for the analysis and interpretation of genomic, transcriptomic, proteomic, spatial, pathology, imaging, molecular modeling and clinical datasets to enable target identification, patient stratification, biomarker discovery, companion diagnostic development, and data-driven decision-making across the company's pipeline. The successful candidate will serve as a key partner to Translational Medicine/Research, Biomarkers and Clinical Development teams and will help shape the organization's long-term data and computational strategy. Role and Responsibilities: Translational Research and Biomarker Development Lead analyses supporting biomarker discovery, patient selection, pharmacodynamic assessments, and mechanisms of response and resistance. Direct integration of multiomic datasets including: Whole exome sequencing (WES) Whole genome sequencing (WGS) RNA sequencing Single-cell sequencing Spatial transcriptomics Proteomics ctDNA Digital pathology and imaging data Collaborate with translational scientists and clinicians to generate biologically meaningful insights that influence clinical development strategy. Support companion diagnostic (CDx) development and regulatory submissions. Molecular modeling of protein-protein interactions Strategic Leadership Develop and execute the company's bioinformatics and computational biology strategy across discovery, translational, and clinical programs. Interface with high-performing team of biochemists, computational biologists, and data scientists. Establish scientific priorities, resource plans, and technology roadmaps aligned with corporate objectives. Evaluate emerging technologies in AI/ML, multiomics, digital pathology, spatial biology, and real…