Senior Clinical Trial Associate

Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/ , and follow us on X , LinkedIn and Facebook . Role Summary: The Senior Clinical Trial Associate (CTA) is a key member of the Clinical Operations team responsible for supporting the successful planning, execution, oversight, and closeout of Dyne’s global clinical trials. This role partners closely with Clinical Study Leads, cross-functional study team members, CROs, vendors, and investigative sites to help ensure trials are delivered with quality, efficiency, compliance, and a strong focus on patients. The S enior CTA contribute s to day-to-day study operations, maintains critical study documentation and tracking tools, supports inspection readiness, and helps establish scalable processes and best practices as Dyne continues to advance its clinical development portfolio. Success in this role requires strong organization, attention to detail, proactive communication, sound judgment, accountability, and the ability to manage competing priorities in a dynamic clinical development environment. This role is based in Waltham, MA. Primary Responsibilities Include : Support the Clinical Study Lead and cross-functional study team across all phases of global clinical trial execution, including feasibility, study planning , start - up, enrollment, maintenance, and closeout activities Partner with the Clinical Study Lead to facilitate effective communication across internal study teams, CROs, vendors, and other external partners, helping to proactively identify risks, resolve issues, and keep study activities on track Track study metrics, operational milestones, site activation progress, enrollment trends, vendor deliverables, and Sponsor oversight activities; work closely with CROs and vendors to ensure tracking tools are accurate , complete, and current Support the review, coordination, and quality control of essential study documents, including informed consent forms, site initiation visit materials, essential regulatory documents, study plans, recruitment materials, manuals, trackers, and other trial-related documents to ensure consistency, accuracy, and compliance Assist with the development , routing, distribution , and maintenance of Sponsor study documents and operational materials, such as protocols, protocol amendments, administrative letters, pharmacy manuals , study reference materials, and team communications Attend internal study team meetings and external CRO/vendor meetings; prepare and maintain agendas, meeting materials, minutes, decision logs, and action item trackers to support accountability and timely follow-through Coordinate logistics and materials for investigator meetings, principal investigator calls, site-facing communications, conferences, vendor meetings, and other study-related forums Collect , file, reconcile, and track essential documents for the trial master file (TMF ); conduct routine TMF reviews , identify gaps, follow up on missing documentation, and support ongoing inspection readiness activities Take initiative to improve Clinical Operations processes by identifying opportunities for standardization, efficiency, quality, and continuous improvement within study teams and across the department Maintain and update study tracking tools, dashboards, contact lists, document logs, training records, and other operational resources to support transparency and timely decision-maki…