Senior Backend Engineer, AI & Bioinformatics (TypeScript)

Sequencing is building the interface between humanity and its DNA. Using clinical-grade whole genome sequencing, AI, and a rapidly expanding ecosystem of genomic applications, we help people better understand themselves, their health, and their future through their DNA. The human genome is one of the most valuable and underutilized resources in the world. Our mission is to transform the human genome into a lifelong source of personalized guidance and build the trusted home for every genome on Earth. As the world’s largest direct-to-consumer whole genome sequencing platform, Sequencing is helping define the future of AI-powered personalized health. We’re a profitable, venture-backed, fully remote company building category-defining products that help people better understand themselves through their DNA. Sequencing is building the interface between humanity and its DNA. Using clinical-grade whole genome sequencing, AI, and a rapidly expanding ecosystem of genomic applications, we help people better understand themselves, their health, and their future through their DNA. The human genome is one of the most valuable and underutilized resources in the world. Our mission is to transform the human genome into a lifelong source of personalized guidance and build the trusted home for every genome on Earth. As the world’s largest direct-to-consumer whole genome sequencing platform, Sequencing is helping define the future of AI-powered personalized health. We’re a profitable, venture-backed, fully remote company building category-defining products that help people better understand themselves through their DNA. ## The opportunity We’re building AI that can reason over one of the most complex datasets in existence: the human genome. We’re creating an entirely new AI platform that combines large language models, bioinformatics, and modern backend engineering to solve problems that haven’t been solved before. As a Senior AI Bioinformatics Engineer, you’ll join a team of senior engineers building the next generation of Sequencing AI. You’ll design and build distributed services, genomic reasoning engines, retrieval systems, and data platforms that enable AI to accurately reason about genes, variants, diseases, medications, and human health. This isn’t about adding AI to an existing product. It’s about inventing new technology that combines whole genome sequencing, bioinformatics, and AI into a platform that millions of people will use to better understand their DNA. We’re looking for someone who enjoys solving difficult engineering problems, writing elegant production code, and turning complex genomic science into scalable AI systems. If you’re equally excited by distributed systems and human genetics, you’ll feel at home here. ## Who you are This role combines two disciplines that rarely exist in the same person: senior AI backend engineering and senior bioinformatics. You should be capable of joining our AI Team as a Senior Backend Engineer while bringing deep expertise in human whole genome sequencing and bioinformatics. You’re equally comfortable discussing distributed systems architecture, AI infrastructure, and data engineering as you are discussing variant interpretation, genomic databases, and human genetics. We’re looking for someone who genuinely excels in both disciplines. We recognize this combination of expertise is rare. This role requires someone who has reached senior-level proficiency in both production software engineering and human bioinformatics and is excited to apply both skill sets to build entirely new AI technology. **AI Backend Engineering** You have: - 5+ years designing, building, and operating production backend systems at scale. - Expert-level TypeScript with experience owning production services end to end. - Strong distributed systems fundamentals - you understand how they’re designed, scaled, and why they fail. - Hands-on experience building large-scale data processing systems using technologies such as Apac…