Scientist, Solid Tumor CAR-T

Legend Biotech is a global biotechnology company dedicated to treating and, one day, curing life-threatening diseases. Headquartered in Bridgewater, New Jersey, we are advancing the next generation of cell therapy through a portfolio of innovative technologies, including autologous, allogeneic, and in vivo cell therapy approaches. Our research spans chimeric antigen receptor T-cell (CAR-T), T-cell receptor (TCR-T), natural killer (NK) cell-based therapies, and other emerging platforms designed to transform the treatment of serious diseases. From our global network of research and development sites, we are committed to discovering and developing safe, effective, and cutting-edge therapies for patients worldwide. Legend Biotech entered into a global collaboration agreement with Johnson & Johnson to jointly develop and commercialize CARVYKTI® (ciltacabtagene autoleucel; cilta-cel). Through this strategic partnership, we combine complementary expertise and capabilities to advance innovative immunotherapies for patients living with multiple myeloma. Legend Biotech is seeking a Scientist, Solid Tumor CAR-T as part of the Research and Development team based in Philadelphia, PA. Role Overview We are seeking a highly motivated Scientist to join our interdisciplinary cell therapy team at Legend Biotech, focused on advancing CAR-T cell therapies for solid tumors. This role is central to our in vivo CAR-T platform and will drive preclinical development from construct design through animal model efficacy studies. The ideal candidate holds a PhD in Immunology, Immuno-Oncology, or a closely related discipline, with up to 3 years of postdoctoral experience. You are a rigorous scientist who thrives in a fast-paced, collaborative environment and is passionate about translating basic immunology insights into transformative oncology therapies. Key Responsibilities Design and execute in vitro CAR-T functional assays. Perform comprehensive phenotypic analysis of T cell differentiation, activation, and memory subsets. Evaluate CAR-T cell trafficking and tumor infiltration in vivo using flow cytometry and immunohistochemistry. Handling and engineering human and murine T cells as well as various cancer cells. Engineering and maintaining various cancer cell lines for model development. Analyze and interpret data, troubleshooting, maintain detailed experimental records. Requirements A scientist in Immunology, Immuno-Oncology, Tumor Immunology, Cancer Biology, or a closely related field. Candidates completing ther PhD within the past 3 years are strongly encouraged to apply. Primary human T cell isolation, activation, lentiviral transduction, and expansion is required. Multicolor flow cytometry: panel design, data acquisition (e.g., Attune,Novocyte, Cytek Aurora), and analysis (FlowJo). Standard molecular biology: PCR/qPCR, lentiviral vector packaging and titration, Western blot. Experience with humanized mouse models for in vivo CAR-T evaluation. Proficiency in CAR-T cell trafficking studies: IHC/IF of tumor sections, in vivo imaging. Familiarity with gene editing tools (CRISPR/Cas9) for cell engineering. Experience with in vitro Organoid cancer model establishment and expansion. Experience in solid tumor indications (e.g., lung, gastric, or other refractory cancers). Contributions to innovation in cell therapy (publications, patents, or conference presentations). #Li-SD1 #Li-Onsite The base pay range below is what Legend Biotech USA Inc. reasonably expects to offer at the time of posting. Actual compensation may vary based on experience, skills, qualifications, and geographic location. The company reserves the right to modify this range as needed and in accordance with applicable laws. Other Types of Pay: Performance-based bonus and/or equity is available to employees in eligible roles. Benefits and Paid Time Off: Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. We offer eight…