Scientist, In Vivo CAR-T Pipeline

Legend Biotech is a global biotechnology company dedicated to treating and, one day, curing life-threatening diseases. Headquartered in Bridgewater, New Jersey, we are advancing the next generation of cell therapy through a portfolio of innovative technologies, including autologous, allogeneic, and in vivo cell therapy approaches. Our research spans chimeric antigen receptor T-cell (CAR-T), T-cell receptor (TCR-T), natural killer (NK) cell-based therapies, and other emerging platforms designed to transform the treatment of serious diseases. From our global network of research and development sites, we are committed to discovering and developing safe, effective, and cutting-edge therapies for patients worldwide. Legend Biotech entered into a global collaboration agreement with Johnson & Johnson to jointly develop and commercialize CARVYKTI® (ciltacabtagene autoleucel; cilta-cel). Through this strategic partnership, we combine complementary expertise and capabilities to advance innovative immunotherapies for patients living with multiple myeloma. Legend Biotech is seeking a Scientist, In Vivo CAR-T Pipeline as part of the Research and Development team based in Philadelphia, PA . Role Overview Legend Biotech is a global leader in the development of innovative cell-based therapies. We are seeking a highly motivated Scientist to join our growing in vivo CAR-T development team. This role provides the opportunity to make a direct scientific impact by advancing our in vivo CAR-T platform from early discovery through preclinical development. The successful candidate will bring deep technical expertise in cell&gene therapy, along with a strong foundation in immunology and virology. You will work in a highly collaborative environment alongside research and early development teams to translate novel scientific concepts into robust therapeutic candidates. This role requires scientific rigor, hands-on execution, intellectual curiosity, and the ability to thrive in a fast-paced research setting. This is a fully onsite, lab-based position located in Philadelphia, PA. Key Responsibilities Design, plan, and execute experimental studies to advance cell and gene therapy platforms and pipeline programs. Conduct and analyze in vitro and in vivo studies to assess product potency, efficacy, and safety. Develop, optimize, and troubleshoot experimental assays, including: Cell line engineering Cell-based functional and cytotoxicity assays ELISA and PCR-based assays High-throughput binder screening Viral vector packaging and titration Analyze and interpret complex datasets and maintain accurate experimental documentation. Prepare clear, high-quality reports and presentations and communicate findings to internal research and cross-functional teams. Requirements PhD in Immunology, Cell Biology, Molecular OR Master’s degree with 3–6+ years of relevant experience Hands-on experience in immunology, cell therapy, gene therapy, or related fields Experience with viral vector systems (especially lentivirus) is highly preferred Industry or postdoctoral experience is a plus #Li-JR1 #Li-Onsite The base pay range below is what Legend Biotech USA Inc. reasonably expects to offer at the time of posting. Actual compensation may vary based on experience, skills, qualifications, and geographic location. The company reserves the right to modify this range as needed and in accordance with applicable laws. Other Types of Pay: Performance-based bonus and/or equity is available to employees in eligible roles. Benefits and Paid Time Off: Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. We offer eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays. Additional voluntary benefits include flexible spending and health savings accounts, life and AD&…