Scientist I, Functional Bioassy & High-Throughput Screening

**The Role:** The Functional Bioassay team is seeking a **Scientist I, Functional Bioassay / High-Throughput Screening** to support the development, optimization, and execution of functional assays across Generate’s growing portfolio of therapeutic programs. This is a bench-focused role for a scientist who enjoys hands-on experimental work and wants to contribute directly to the generation of high-quality functional data at scale that informs AI/ML-enabled protein therapeutic design and program decisions. The successful candidate will support and, where appropriate, design, optimize, and troubleshoot biochemical and cell-based assays; execute high-throughput screening campaigns; analyze assay data; and help integrate automation into HTS workflows across multiple program areas. Key areas of focus may include ion channel, GPCR, ADC-related functional HTS assays, and other cell-based or biochemical screening platforms as portfolio needs evolve. This role is expected to be approximately 80–90% laboratory-based and will require close collaboration with scientists across the Therapeutics organization, Data Science, research leads, automation colleagues, and cross-functional program teams to accelerate closed-loop experimental cycles. The scientist will help advance platform-wide innovation in assay execution, data quality, automation onboarding, and workflow scalability. This position is well-suited for an early-career scientist with strong technical skills, curiosity to learn new assay systems, clear communication skills, and a desire to grow in a fast-paced, collaborative biotech environment while contributing meaningfully to therapeutic discovery programs. **Here's how you will contribute:** - Design, optimize, and implement HTS-compatible biochemical and cell-based assays, with appropriate integration of automation. - Execute plate-based HTS campaigns, analyze results, and interpret complex experimental datasets. - Clearly communicate findings to program teams to support AI/ML-enabled design cycles, program prioritization, and iterative therapeutic optimization. - Support multiple therapeutic programs as a functional assay contributor, with potential focus areas including ion channel, GPCR, and ADC-related assays. - Learn and apply new assay technologies, including ion channel and GPCR functional assays, with guidance from senior team members and internal or external subject matter experts as needed. - Perform laboratory experiments with attention to detail, scientific rigor, and adherence to established protocols. - Troubleshoot assay performance, instrumentation, reagent, or workflow issues in partnership with senior scientists and automation colleagues. - Maintain accurate, timely, and well-organized records in electronic laboratory notebooks and other data systems. - Prepare clear summaries of experimental results for internal team discussions, program updates, and cross-functional meetings. - Collaborate with colleagues across Functional Bioassay, Automation, Biology, Protein Sciences, Data Science, and program teams to ensure experiments are well coordinated and aligned with project needs. - Follow laboratory safety practices, sample handling requirements, data integrity expectations, and Generate’s scientific standards. **The Ideal Candidate will have:** - PhD in cell biology, pharmacology, immunology, biochemistry, bioengineering, molecular biology, or a related discipline, with relevant hands-on laboratory experience; or MSc with approximately 4+ years of relevant industry or academic research experience; or BSc with approximately 6+ years of relevant industry or academic research experience - Hands-on experience with cell-based, biochemical, or functional assays in an academic, biotech, pharmaceutical, or related research setting. - Strong technical foundation in mammalian cell culture and plate-based assay workflows. - Experience executing experiments with careful attention to controls, replicates, data quality, and…