Scientist, Advanced Cell Models & Delivery Biology

**Overview** The successful candidate will develop and apply advanced in vitro cellular models to support the discovery and optimization of novel delivery strategies for RNAi therapeutics. This individual will play a key role in evaluating ligand-mediated delivery, receptor biology, cellular uptake, and pharmacological activity across multiple therapeutic areas. This position is **onsite** and will be primarily located in Cambridge, MA. **Key Responsibilities** - Work collaboratively with internal teams and external partners to establish, optimize, and apply advanced 2D and 3D cellular models, including primary cell systems, co-cultures, organoids, spheroids, and microphysiological systems. - Design and execute studies to evaluate receptor-mediated delivery, ligand activity, cellular uptake, and target engagement of RNAi therapeutics. - Identify gaps in existing model capabilities and develop novel cellular systems to address emerging scientific questions and program needs. - Utilize imaging-based technologies, protein-based assays, and molecular biology techniques to characterize receptor expression, uptake mechanisms, and biological responses. - Generate mechanistic insights to support ligand selection, delivery optimization, and candidate progression across therapeutic programs. - Collaborate closely with other teams to design and execute experiments that inform key project decisions. - Evaluate the predictive value and translational relevance of in vitro models and contribute to the advancement of next-generation cellular platforms. - Communicate scientific findings effectively through presentations, reports, and cross-functional discussions. - Prepare clearly articulated experimental reports and data presentations. **Qualifications** - Ph.D. in Cell Biology, Molecular Biology, Pharmacology, Biomedical Engineering, or a related biological discipline with 0-3 years of industry and/or post-doctoral experience. - Strong hands-on experience with advanced in vitro cellular systems, including primary cells and complex 2D/3D culture models such as organoids, spheroids, co-cultures, tissue slices, or microphysiological systems. - Experience developing and applying cell-based assays to address mechanistic and translational research questions. - Experience in one or more of the following areas: receptor biology, cellular uptake, intracellular trafficking, ligand-receptor interactions, imaging, or protein-based characterization methods. - Strong experimental design, troubleshooting, and data interpretation skills. - Self-motivated, collaborative, and able to manage multiple priorities in a fast-paced research environment. - Excellent communication and presentation skills. Preferred Qualifications - - Experience with oligonucleotide therapeutics, RNAi, ASOs, peptides, antibodies, or targeted delivery technologies. - Experience with advanced imaging platforms, quantitative image analysis, or receptor-mediated delivery systems. - Experience with cardiac cell systems, including primary, iPSC-derived, or advanced in vitro cardiac models. #LI-JR1 **U.S. Pay Range** **$110,400.00 - $165,600.00** The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family…