Principal Technical Program Manager

About Gruve Gruve is an innovative software services startup dedicated to transforming enterprises to AI powerhouses. We specialize in cybersecurity, customer experience, cloud infrastructure, and advanced technologies such as Large Language Models (LLMs). Our mission is to assist our customers in their business strategies utilizing their data to make more intelligent decisions. As a well-funded early-stage startup, Gruve offers a dynamic environment with strong customer and partner networks. About the Role We are seeking a highly experienced Principal Technical Program Manager to lead large-scale, cross-functional programs across Life Science Group (LSG) and Clinical Diagnostics Group (CDG) initiatives. This role will drive program execution, R&D alignment, AI/ML innovation, platform modernization, and regulatory-compliant product delivery within a highly regulated environment. Key Responsibilities Program & R&D Leadership Lead end-to-end delivery of multi-team programs across LSG and CDG product portfolios. Serve as the primary technical program interface between R&D and engineering teams. Translate research and laboratory innovations into scalable platform development roadmaps. Drive AI/ML initiatives, including computer vision, predictive diagnostics, and LLM-assisted documentation. Facilitate cross-functional alignment and provide executive-level program updates and recommendations. Present risk mitigation strategies and resolution plans to senior leadership and executive stakeholders. Architecture & Delivery Excellence Participate in architecture reviews and guide build-versus-buy decisions. Establish and maintain SAFe/hybrid-agile program management practices. Define and govern program milestones, OKRs, dependencies, and risk management processes. Drive CI/CD and DevSecOps adoption for embedded software and instrument development teams. Develop executive-ready reporting and mentor program managers and project leads. Basic Qualifications Bachelor's degree in Computer Science, Biomedical Engineering, Biochemistry, Engineering, or a related discipline. 12+ years of experience leading complex, cross-functional technical programs with budgets exceeding $5M. Proven experience leading enterprise application programs throughout the software development lifecycle (SDLC), including Salesforce, SAP, Microsoft ecosystem technologies, enterprise integrations, business process automation, and platform modernization initiatives. Strong experience managing programs within Life Sciences, Diagnostics, Medical Devices, or regulated healthcare environments. Experience with SAFe, LeSS, Agile-at-Scale methodologies, Program Increment planning, and Agile Release Train facilitation. Deep understanding of IVD product development lifecycle and regulatory frameworks, including: 21 CFR Part 11 IEC 62304 ISO 13485 Experience supporting molecular biology workflows such as PCR, ddPCR, electrophoresis, or flow cytometry. Strong background in embedded systems, instrument software, firmware, and hardware development programs. Knowledge of cloud-native platforms (AWS and/or Azure), APIs, microservices, CI/CD, and DevSecOps practices. Experience managing AI/ML program delivery, model governance, and enterprise AI initiatives. Strong executive communication and stakeholder management skills. Preferred Qualifications Master's degree or PhD in Life Sciences, Biomedical Engineering, Computer Science, or a related field. PgMP, PMP, SAFe SPC, or equivalent program management certification. Experience with laboratory environments, including CLIA, CAP, QC systems, and proficiency testing. Familiarity with New Product Introduction (NPI) governance processes. Experience with platform engineering, Infrastructure as Code (IaC), and developer platform strategies. Working knowledge of embedded software development using C/C++ and Python. Experience with enterprise AI platforms such as Claude, Azure OpenAI, or similar technologies. Familiarity with enterprise systems i…