Principal Scientist, Medicinal Chemistry

## Who We Are: Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in patients with Prader-Willi syndrome, endometriosis\* and uterine fibroids\*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit [neurocrine.com](https://c212.net/c/link/?t=0&l=en&o=4450443-1&h=3502828688&u=https%3A%2F%2Fc212.net%2Fc%2Flink%2F%3Ft%3D0%26l%3Den%26o%3D4252873-1%26h%3D4039787179%26u%3Dhttps%253A%252F%252Fwww.neurocrine.com%252F%26a%3Dneurocrine.com&a=neurocrine.com), and follow the company on [LinkedIn](https://c212.net/c/link/?t=0&l=en&o=4450443-1&h=884458364&u=https%3A%2F%2Fc212.net%2Fc%2Flink%2F%3Ft%3D0%26l%3Den%26o%3D4252873-1%26h%3D928986078%26u%3Dhttps%253A%252F%252Fwww.linkedin.com%252Fcompany%252Fneurocrine-biosciences%26a%3DLinkedIn&a=LinkedIn), [X](https://c212.net/c/link/?t=0&l=en&o=4450443-1&h=1730331693&u=https%3A%2F%2Fc212.net%2Fc%2Flink%2F%3Ft%3D0%26l%3Den%26o%3D4252873-1%26h%3D3255611529%26u%3Dhttps%253A%252F%252Ftwitter.com%252Fneurocrine%26a%3DX%2B%28formerly%2BTwitter%29&a=X), [Facebook](https://c212.net/c/link/?t=0&l=en&o=4450443-1&h=3526407131&u=https%3A%2F%2Fc212.net%2Fc%2Flink%2F%3Ft%3D0%26l%3Den%26o%3D4252873-1%26h%3D1536396415%26u%3Dhttps%253A%252F%252Fwww.facebook.com%252FNeurocrine%26a%3DFacebook&a=Facebook) and [YouTube](https://www.youtube.com/@NeurocrineBiosciencesInc). (*\*in collaboration with AbbVie*) ## About the Role: Responsible for devising the medicinal chemistry strategy on projects. May lead or co-lead multi-disciplinary project teams to advance discovery programs to key milestones. Provides expertise in medicinal chemistry principles, complex small molecule synthesis, purification, and data analysis. Supervises and mentors both internal direct reports and external CROs towards hypothesis driven chemistry strategies. Monitors and evaluates completion of tasks and projects. Contributes to development of policies and department strategies. \_ ## Your Contributions (include, but are not limited to): - Leads projects and initiatives in the rapid optimization of lead molecules utilizing modern technology available to medicinal chemists such as automated synthesis and purification - Distills complicated, multidimensional data to clear hypotheses and new experimental directions - Imports new principles/concepts to develop useful new experimental approaches - Researches external intellectual property relevant to project(s) and areas of pursuit - Contributes substantively to patent and publication preparation - Responsible for designing, planning, and conducting synthesis of analog libraries as well communicates results to the project or program team - Participates in a multidisciplinary team committed to the continuous improvement of the lead optimization process as well as the expeditious identification of development compounds - Plans and manages projects. Represents Medicinal Chemistry on cross-functional teams. Maintains accountability for deliverables and progress for projects - Independently designs, plans and executes activities towards the goals of one or more Medicinal Chemistry projects to support lead generation through pre-clinical activities - Supervis…