Principal Scientist, Delivery

## **Opportunity for Secondment to AskBio** We’re pleased to share an exciting secondment opportunity at AskBio. This role is available for a time period to be determined by leadership at both Bayer and AskBio. While most assignments range from one to two years, the exact duration will be based on business needs and mutual agreement. This secondment offers a unique chance to broaden your experience, expand your knowledge, and contribute meaningfully to AskBio’s mission: to advance gene therapy and change the lives of patients around the world. If you’re interested in exploring this opportunity, we encourage you to: - **Speak with your direct manager** to discuss your interest and alignment with your development goals. - **Apply directly** using the link provided in the posting. We look forward to seeing how our colleagues continue to grow and make an impact across the Bayer-AskBio partnership. **Our vision:** Pioneering science to create transformative molecular medicines. **Our mission:** Lead innovative science and drive clinical outcomes to transform people's lives. **Our principles:** - Advance innovative science by pushing boundaries. - Bring transformative therapeutics to patients in need. - Provide an environment for employees to reach their fullest potential. **Our values:** - Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need. - Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view. - Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers. - Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action. - Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what’s right in every situation. Make clear commitments and follow through. **Position Summary** AskBio is seeking a highly accomplished, innovative, and collaborative Principal Scientist to lead capsid discovery and development efforts within the Delivery group in R&D. This role is responsible for advancing next‑generation AAV capsid technologies that support AskBio’s pre-clinical and clinical gene therapy pipeline. The Principal Scientist will operate as a scientific leader and people leader, providing strategic and technical direction for capsid library design, screening, and characterization efforts. The ideal candidate will have deep hands‑on experience with AAV capsid library screening methodologies, AAV production, and associated molecular and NGS‑based workflows, and will demonstrate the ability to think independently, generate new scientific ideas, and translate complex experimental and analytical data into actionable program decisions. Working closely with cross‑functional partners—including bioinformatics, vector biology, translational, and therapeutic teams—the Principal Scientist will oversee multiple high‑impact projects, provide scientific ownership of integrated biology‑and‑data workflows, and contribute to the long‑term evolution of AskBio’s capsid and delivery platforms. The role is based in Research Triangle Park, NC. **About You** - You are a highly independent scientific thinker who thrives in ambiguity and can take an abstract biological or technical question and turn it into a clear, executable experimental strategy. - You consistently generate new ideas and approaches, challenge assumptions, and look beyond established methods to advance capsid and delivery technologies. - You operate as a go‑to expert in your domain, influencing decisions through data quality, clarity of thinking, and scientific judgment. - You have experience leading people and thrive in cross-functional teams, leading without detailed instruction and able to balance strategic vision with hands-on…