Principal Research Scientist I, In Vitro Preclinical Development

## Company Description **About AbbVie** AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at [www.abbvie.com](http://www.abbvie.com/). Follow @abbvie on [LinkedIn,](https://www.linkedin.com/company/abbvie/) [Facebook](https://www.facebook.com/AbbVieGlobal/), [Instagram](https://www.instagram.com/abbvie/), [X](https://twitter.com/abbvie) and [YouTube.](https://www.youtube.com/user/AbbVie) ## Job Description AbbVie is seeking a driven Principal Research Scientist I, In Vitro Preclinical, to join the mRNA-tLNP group. The Principal Research Scientist I, In Vitro Preclinical, will lead the design and development of innovative CAR T-cell therapies that advance mRNA-tLNP pipeline programs from early discovery through IND-enabling studies, with an emphasis on applications in oncology and autoimmune diseases. **Responsibilities:** - Effectively function as a Principal Investigator within the In Vitro Preclinical Team, developing and implementing original research and development strategies for innovative in vivo CAR T-cell therapies. - Demonstrate creative 'out of the box' thinking to solve difficult problems and champion new technologies to achieve project goals. - Collaborate with Biotherapeutics and Genetic Medicine stakeholders to address key CAR-T therapeutic challenges in mRNA-tLNPs through preclinical composition design. - Serves as the organizational SME in next-generation cell therapy engineering, with deep command of synthetic receptor architecture and functional signaling biology, and the ability to rapidly synthesize the evolving scientific and intellectual property landscape into high-impact therapeutic programs. - Oversee CAR-T project execution from inception through preclinical stages, ensuring alignment with therapeutic hypotheses, available datasets, and the competitive landscape. - Generate new scientific proposals and lead those efforts. Anticipate and critically evaluate scientific or regulatory advances or competitive threats and respond with appropriate new strategies. - Represent project teams by communicating scientific strategy, progress, and risk assessment to stakeholders. - Primary author of publications, presentations, regulatory documents and/or primary inventor of patents. - Present at leading scientific conferences. Enhance AbbVie’s reputation by presenting research findings and innovative ideas to stakeholders and collaborators. - Mentor/supervise a team of one or more and evaluate the performance of those individuals; is accountable for the effective performance of the team/individuals. ## Qualifications - BS or equivalent education and extensive with typically 14+ years of experience; MS or equivalent education with typically 12+ years of experience; PhD with typically 6+ years of experience in CAR T-cell or immunotherapeutic field - Deep subject matter expertise in CAR-T biology, including genetic medicine approaches, novel biological systems, and assay development for candidate generation and assessment. - Demonstrated ability to function as a principal investigator, generating original technical ideas and research or development strategies. - Demonstrate creative 'out of the box' thinking to solve difficult technical problems and champion new technologies to achieve project goals. - Experienced and demonstrated success as primary author of publications, presentations, regulatory documents and/or primary inventor of patents. - Demonstrated scientific communication and presentation skills by presenting at leading scientific conferences. - Exceptional project management and multitasking skills; adept at setting and managing timeline…