Platform Lead, In Vivo Studies Coordinator

***Title:*** Platform Lead – In Vivo Studies Coordinator ***Location:*** Princeton, NJ or Los Angeles, CA (currently hybrid) - must work 3 days per week from office. ***Reports To:*** Preclinical VP overseeing the Therapeutics in In Vivo Systems (TIPS) Team ***Salary Range:*** $130,000 – $200,000. Exact compensation will vary based on experience ***Other:*** Vaccination against COVID-19 is a prerequisite for employment at CHDI Management ***About CHDI Foundation, Inc.*** CHDI Foundation, Inc. is a privately funded nonprofit biomedical research organization exclusively dedicated to collaboratively developing therapeutics that will substantially improve the lives of those affected by Huntington’s disease (HD). CHDI has assembled a team of scientists and other professionals working in offices located in Los Angeles, New York City, and Princeton, NJ. Our scientists work closely with a network of more than 700 researchers in academic and industrial laboratories around the world in the pursuit of these novel therapies, providing strategic scientific direction to ensure that our common goals remain in focus. CHDI works to increase the understanding of HD in order to hasten the development of therapeutic approaches. To achieve this goal, CHDI manages a diverse portfolio of research projects through a novel virtual model that encourages scientific collaboration, one which more directly connects academic research, drug discovery and clinical development. This helps bridge the translational gap that often exists between academic and industrial research pursuits and that adds costly delays to therapeutic development. In its role as a collaborative enabler, CHDI seeks to bring the right partners together to identify and address critical scientific issues and move drug candidates to clinical evaluation as rapidly as possible. Our activities extend from exploratory biology to the identification and validation of therapeutic targets, and from drug discovery and development to clinical studies and trials. More information about CHDI can be found at http://www.chdifoundation.org. ***Job Description:*** We are seeking a scientist with extensive prior experience in the coordination of preclinical in vivo rodent model studies in relation to 1) disease modeling, and 2) preclinical evaluation of therapeutic drug candidates for disease indications. In this role, you will support CHDI Scientific Directors to design, implement and execute in vivo (and downstream ex vivo) studies throughout our global Contract Research Organization collaborator network in support of Huntington’s disease research. This would include providing support and advice on breeding paradigms, experimental animal selection, optimized experimental design, and active monitoring of experiment execution to ensure adherence to workplans and SOPs. In addition, you will provide logistical coordination across our CRO providers to execute studies to maximize efficiency in cycle time, while maintaining high quality services and data delivery. ***Job Responsibilities:*** - Support the full design and implementation of testing paradigms of preclinical proof-of-concept tool molecules in rodent models relevant to Huntington’s disease (HD) research across a wide range of modalities (ie small molecule, ASO, RNAi, CRISPR, virally delivered reagents). - Support scientific directors with the full implementation of animal model studies to mechanistically evaluate targets of HD onset and progression emerging from HD human genetic studies, using genetically modified animal models. - Manage the activities of external CROs / vendors for relevant in vivo services, and provide qualification of data and reports in area of responsibility. - Support DMPK colleagues and other CHDI Scientific Directors across teams to aid diverse drug discovery and gene therapy programs with respect to pharmacokinetic - pharmacodynamic assay deployment in rodent models. - Participate in technology assessment and implementation…