Pioneering Medicines: Director, In Vivo Pharmacology - Metabolic Disease

What if... We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner? About Pioneering Medicines: Pioneering Medicines, Flagship Pioneering’s in-house drug development unit, is dedicated to conceiving and developing a broad portfolio of life-changing treatments for patients built from Flagship’s innovative platforms. Harnessing the drug development expertise of its team together with the power of Flagship's multiple scientific platforms, Pioneering Medicines explores and identifies new product concepts which are then advanced jointly with Flagship’s bioplatform companies. Within Flagship’s Innovation Supply Chain partnerships, Pioneering Medicines works with external collaborators to apply its unique approach to partners’ R&D priorities. These partnerships are highly co-creative strategic alliances that accelerate therapeutic innovation by bringing together partners spanning the full spectrum of drug discovery, development, and production. Position Summary : Pioneering Medicines is seeking a highly motivated and strategic Director of in vivo Pharmacology to support a growing portfolio of assets. This key role will require an individual to direct and oversee in vivo pharmacology efforts, participating in drug discovery and early development activities. The role will involve functional accountability to support assets across a diverse range of modalities using their deep expertise in obesity and metabolic diseases. The candidate will work in cross-functional teams leading and supporting the activities, delivering research leadership, and managing/mentoring junior scientists. The successful candidate is expected to proactively build and maintain strong collaborations with Flagship Pioneering platform companies and large pharma partners. We are seeking individuals who are analytical, goal-oriented, and timeline-sensitive, while maintaining the highest of scientific and ethical standards. Strong communication skills and comfort working in a dynamic and cross-functional team environment are required. Responsibilities: Represent the in vivo pharmacology function on drug discovery project teams, supporting assets in obesity and metabolic diseases Identify and implement in vivo efficacy and PK/PD models to support assessment of lead small molecules, antibodies, peptides and genetic modalities, with a focus on disease-relevant endpoints, PD, and target-specific biomarkers Participate in partnerships and collaboration efforts with Flagship Platform companies and external pharmaceutical partners Collaborate closely across functions such as in vitro pharmacology, DMPK/Tox, and translational sciences to advance programs to development candidate and IND-enabling studies Management of direct report/s to execute internal studies and manage studies at external CROs to achieve program goals This position is on-site/hybrid in Cambridge, MA and requires hand-on experience and being in the lab Contribute to discussions with internal project teams, external partners and consultants in developing comprehensive in vivo strategic plans Work closely with other FSP companies to develop research strategies and evaluate new programs. Basic Qualifications: PhD + 10 or more years of industry experience or MS with 12+ years of industry experience within in vivo pharmacology or related discipline Strong understanding of PK/PD assessments in models of disease Experience in designing ex vivo studies to assess PD and target engagement endpoints, is a must-have. Proficient experience using rodent metabolic and behavioral cage systems and metabolic phenotyping technologies In-depth hands-on expertise with in vivo models of obesity and metabolic diseases. Cardiovascular experience preferred. Experience and managing in vivo personnel in a dynamic and fast-paced research environment preferred. Additional Qualifications and Skills: Experience working with standard modalities, such as small molec…