Manager / Senior Manager, R&D Finance

Company Overview Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been accepted by the U.S. FDA; IM-1021, a clinical-stage ROR1 ADC; IM-1617, a clinical-stage solid tumor ADC; and IM-3050, a clinical-stage FAP-targeted radioligand therapy. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets. Position Overview We are seeking an experienced and versatile Manager / Senior Manager to join our R&D Finance team, which serves as the primary finance business partner to R&D teams across the organization. The primary focus of this role is clinical trial finance—owning the accruals, forecasting, reporting, and business partnership for an assigned portfolio of clinical studies—while also flexing to support additional areas across the R&D organization as the pipeline grows and matures. This individual will serve as the primary finance point of contact for the functions and processes within their areas of ownership, providing a single point of communication that reduces redundancy by owning the information, knowledge, and relationships tied to those areas. In practice, that means bringing operational intelligence to financial data and financial perspective to operational discussions. Success in this role requires a multi-tool player who thrives in a fast-paced, high-growth, startup-stage environment; someone who gets up to speed quickly, is comfortable operating amid ambiguity and change, and is eager to take on new responsibilities and continuously improve how the team works. Responsibilities Clinical Trial Finance Own the monthly accrual process for an assigned portfolio of clinical trials, developing a deep understanding of how ongoing study activity is tracked and translating that activity into accurate , well-supported accruals—recognizing the significant overlap between building accruals and clinical trial modeling. Develop and maintain detailed clinical trial forecasts and budgets that incorporate evolving study circumstances, including enrollment rates, site activations, protocol amendments, vendor activity, and other pivots common in clinical development. Analyze clinical trial expense variances against study operational metrics to determine whether variances are temporary in nature or reflect permanent, structural changes to a study's cost profile; prepare clear variance commentary and study-level financial summaries that contextualize expenses against study status. Partner with Clinical Operations study managers and Development leaders to understand study plan pivots, enrollment challenges, and vendor performance, and proactively flag operational developments likely to carry near- or long-term financial implications. Manage purchase orders, contract reconciliation, and resolution of vendor invoice issues for assigned studies; partner with the Controllership organization and Procurement to ensure accurate spend tracking and correct coding. R&D Accounting & Monthly Close Serve as the preparer for month-end close activities in areas of ownership, including preparation of accruals, journal entries, account reconciliations, and supporting documentation. Perform flux and variance analysis and respond to accounting-related questions on actuals for owned areas, ensuring activity is recorded in accordance with US GAAP and internal accounting policies. Track department-level purchase orders and expenses as part of the close to ensure accurate and complete spend capture. Partner with Accounting to support timely , accurate close processes; close deliverables are reviewed by accounting…