Lead Medical Safety Physician

For more than 25 years, Corcept has been singularly focused on the science of cortisol, a powerful hormone that when unregulated, can play a role in a broad range of diseases. Our commercial portfolio includes treatments for hypercortisolism and oncology, and the company has discovered more than 1,000 proprietary selective cortisol modulators and glucocorticoid receptor antagonists. With advanced clinical trials in patients with hypercortisolism, solid tumors, ALS and liver disease, Corcept is unlocking the power of cortisol modulation to help address some of the most devastating diseases patients face today. Corcept is headquartered in Redwood City, California. To learn more, visit [www.corcept.com](https://nam10.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.corcept.com%2F&data=05%7C02%7Cgcastrence%40corcept.com%7C8262d50a280e4da5b72208de91a94917%7Cf75457eed65640339f048a7aedb19388%7C0%7C0%7C639108353411832645%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=Yc8odS9%2FPf%2B7kSorJ4ftwNYbnrVi9jKto%2BkzxHyv3ZA%3D&reserved=0). Reporting to the Vice President, Head of Patient Safety & Pharmacovigilance, this role will be responsible for leading the Medical Safety Physician function, ensuring the quality, consistency, and medical integrity of safety assessments across the portfolio. The individual will provide oversight of medical review, signal evaluation, and benefit–risk assessments across clinical development and post-marketing programs. - Operate as a peer functional leader alongside the Head of Safety Science, Head of Safety Operations, and QPPV(s) within the Patient Safety & Pharmacovigilance organization, partnering to provide strategic leadership, ensure effective governance, and maintain an integrated approach to patient safety and pharmacovigilance across the portfolio - Partner with key internal stakeholders, including Clinical Development and Medical Affairs to ensure alignment of safety insights across the product lifecycle while maintaining independent medical judgment on safety and benefit–risk decisions **Responsibilities:** Medical Safety Leadership - Define and drive the medical safety strategy across the portfolio - Provide senior medical safety leadership for safety interpretation and benefit–risk assessment - Ensure consistent medical oversight of clinical and post-marketing safety activities Team Leadership - Lead, build, and develop a team of Medical Safety Physicians - Set standards for medical review quality and consistency - Scale the organization to support portfolio and geographic growth Safety Review & Surveillance - Lead medical evaluation of safety signals in partnership with Safety Science - Ensure robust benefit–risk assessment across programs - Integrate clinical interpretation into safety surveillance outputs Key Collaboration - Partner with Clinical Development to integrate safety into development strategy - Partner with Medical Affairs to ensure consistent safety messaging - Provide medical interpretation and benefit–risk input to cross-functional decisions Regulatory & Governance - Oversee medical input into DSURs, PADERs, and regulatory safety submissions - Support health authority interactions and safety queries - Contribute to cross-functional safety governance forums, providing medical expertise and benefit–risk input in cross-functional safety governance forums Risk Management - Identify and escalate safety risks at product and portfolio level - Define medical risk mitigation strategies with cross-functional partners - Drive continuous improvement in medical safety processes and standards **Preferred Skills, Qualifications and Technical Proficiencies:** - MD required; board certification in a relevant specialty strongly preferred - 12+ years of progressive leadership experience in the pharmaceutical or biotechnology industry, including significant experience in Medical Safety and pharmacovigila…