Director, Clinical Business Operations

The Position At Maze Therapeutics, we believe precision medicine has the power to transform the lives of patients with both common and rare diseases. As Director, Clinical Business Operations, you will serve as a strategic business partner to the Head of Clinical Operations and the Clinical Development organization. Working closely with Finance and cross-functional stakeholders, you will provide direction for the financial planning, budgeting, contracting, and operational business processes that support efficient and predictable clinical trial execution. In partnership with the Head of Clinical Operations, Oversight Directors, Study Leads, and Clinical Development functional leaders, you will oversee study and program budgets, financial forecasting, vendor financial management, and clinical business operations across the development portfolio. You will help build scalable processes, establish budgeting standards, and provide the financial insights needed to support informed business decisions while maintaining sound fiscal stewardship. This role requires a highly collaborative professional who enjoys solving complex operational challenges and working across Clinical Operations, Safety, Biometrics, Finance, Procurement, Legal, and external partners to support operational effectiveness and organizational success. The Impact You’ll Have Clinical Business Operations Leadership Serve as a strategic business partner to the Head of Clinical Operations, providing financial and operational guidance to the Clinical Development organization. Develop scalable business processes, governance models, and operational standards that improve forecasting accuracy, budget visibility, and operational quality and decision-making. Oversee Clinical Development's preferred vendor program by evaluating emerging vendors, establishing strategic partnerships, and maintaining a strong network of qualified providers that support current and future development programs. Establish standardized budgeting methodologies, templates, assumptions, and financial tools aligned with industry benchmarks and organizational needs. Develop dashboards and KPIs that provide visibility into budget performance, vendor spend, forecasting accuracy, contracting timelines, and operational efficiency. Budget Strategy & Financial Management: Oversee development of study budgets from protocol planning through study closeout, ensuring budgets appropriately reflect study objectives and operational requirements. Partner with Clinical Study Leads and Oversight Directors and Clinical Development Functional Leads to develop realistic financial forecasts and proactively manage study financial risks. Collaborate closely with Finance to support monthly accruals and forecasting, quarterly financial updates, annual operating plans, and long-range portfolio planning. Monitor study financial performance, identify budget variances, and develop mitigation strategies to maintain financial objectives. Prepare executive-level financial analyses, dashboards, and budget reporting to support portfolio and corporate decision-making. Ensure vendors maintain accurate change logs and communicate budget impacts in a timely and transparent manner where applicable. Contract & Budget Negotiations Facilitate negotiations for CRO, vendor, and clinical site budgets, balancing market competitiveness, operational requirements, study timelines, and organizational financial objectives. Partner with Legal to support negotiation and execution of Master Service Agreements (MSAs), work orders, study budgets, site budgets, change orders, and other clinical service agreements. Develop negotiation strategies, templates, and playbooks that establish organizational standards and improve consistency across studies. Serve as the Clinical Operations subject matter expert for financial negotiations, providing strategic guidance to Study Leads, Oversight Directors, and senior leadership. Maintain awareness of industry pricing tren…