Director, Alliance Management

Company Overview Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer. Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer. This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing. The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts. Summary The Associate Director/Director, Alliance Management is responsible for leading and optimizing strategic collaborations with pharmaceutical, biotechnology, academic, and technology partners. This role serves as the primary relationship manager for one or more high-value alliances, ensuring alignment of strategic objectives, effective governance, operational excellence, and successful execution of contractual obligations. The successful candidate will work cross-functionally with Research, Clinical Development, Regulatory Affairs, Commercial, Legal, Finance, Manufacturing, and Executive Leadership to maximize the value of partnerships while proactively identifying and mitigating risks. The ideal candidate is a strategic, collaborative leader who excels at building trusted partnerships and navigating complex cross-functional environments and coordinating across internal and external stakeholders. They combine scientific understanding with business acumen, possess exceptional communication and influence skills, and have a demonstrated ability to maximize the value of strategic biotechnology alliances while ensuring operational excellence and long-term partner success. They drive alignment between internal priorities and partner expectations and ensure that Tango has a reputation as a good partner. Your Role: Strategic Alliance Leadership Serve as the primary alliance manager for strategic research, development, licensing, and commercialization partnerships Develop and execute alliance management strategies aligned with corporate objectives Foster trusted relationships with partner organizations at operational and executive levels Ensure partnerships achieve agreed milestones, deliverables, and value creation objectives Governance & Collaboration Establish and manage joint governance committees, including Joint Steering Committees (JSCs), Joint Development Committees (JDCs), and Joint Project Teams Plan governance meetings, prepare agendas, facilitate discussions, document decisions, and track action items Ensure effective communication and decision-making across partner organizations Coordinate escalation and resolution of strategic or operational issues Contract & Financial Management Monitor compliance with collaboration agreements, licensing terms, and governance obligations Coordinate milestone tracking and financial obligations, including payments, royalties, and budget planning Partner with Legal on amendments, contract interpretation, and issue resolution Support alliance-related forecasting and financial reporting Monitor execution against project timelines and contractual commitments Issue Resolution & Risk Management Identify emerging partnership risks and develop mitigation strategies Facilitate conflict resolution while maintaining productive long-term relationships Escalate significant issues to executive leadership as appropriate Performance Monitoring Develop and monitor alliance performance metrics and KPIs Conduct periodic health assessments of strategic partnerships Recommend continuous improvement initiatives to enhance collaboration effectiveness Excellent project management capabilities to manage respective alliances Executive Communication Prepare executive-level presentations, dashboards, and alliance status repo…