Associate Director, Real-World Evidence & Epidemiology

POSITION SUMMARY: We are seeking a Principal Clinical Scientist / Associate Director of Real-World Evidence & Epidemiology to drive observational evidence strategy for our Early Cancer Detection (ECD) portfolio. Population-scale liquid biopsy screening requires robust real-world evidence demonstrating clinical utility, clinical decision-making impact, and downstream patient outcomes. This ownership role uses real-world datasets to accelerate standard-of-care implementation across oncology diagnostics. Working with a builder mindset, you will partner across Clinical Science, Medical Affairs, Market Access, and Data Science to convert population-scale observational data into actionable clinical implementation strategies. PRIMARY RESPONSIBILITIES: Epidemiology and Observational Research Strategy Lead the design, protocol development, and execution of prospective observational studies, registries, and retrospective database assessments across early cancer detection programs Shape post-market evidence generation strategies by isolating critical clinical utility and implementation hurdles that can be resolved via real-world data assets Translate clinical and market requirements into rigorous, practical study designs, specifying target populations, clinical endpoints, and analytic frameworks Systematically identify and mitigate sources of bias, confounding factors, and missing data variance inherent in real-world healthcare datasets Design protocols evaluating clinical utility across diverse populations, ensuring the data generated directly supports precision interventions for individual patients and families Cross-Functional Scientific Leadership Partner across Clinical Science, Medical Affairs, Product Management, and Market Access to prioritize evidence generation initiatives based on regulatory and clinical urgency Collaborate with Biostatistics and Data Science to engineer statistical analysis plans, interpret data findings, and deliver clinical contextualization Extract empirical evidence from early commercial and Laboratory Developed Test (LDT) cohorts to isolate adoption variables, diagnostic compliance, and real-world clinical workflows Deliver real-world data assets that dismantle payer coverage barriers and ground product positioning strictly in clinical utility metrics Evidence Dissemination and External Engagement Convert complex epidemiological findings into clear, high-integrity scientific narratives for internal product governance and external healthcare stakeholders Spearhead the development of peer-reviewed abstracts, posters, presentations, and core manuscripts for major oncology and diagnostic conferences Engage with external clinical collaborators, investigators, and key opinion leaders (KOLs) to advance the platform base for early cancer detection QUALIFICATIONS: Advanced degree (PhD, MPH, MS, PharmD, or equivalent scientific credential) in epidemiology, health outcomes research, biostatistics, or a highly quantitative field 7+ years of experience leading real-world evidence generation, observational clinical research, or HEOR portfolios within the life sciences industry Documented experience executing observational studies across the entire asset lifecycle, from initial protocol drafting through statistical analysis and publication Deep data competency across real-world data sources, including longitudinal medical claims, electronic health records (EHR), and clinical registries Direct experience in oncology clinical trials, molecular diagnostics, or early cancer detection programs is preferred KNOWLEDGE, SKILLS, AND ABILITIES: Take full ownership of complex clinical portfolios as an autonomous strategist Rigorous analytical skills with the ability to pressure-test study assumptions and ground major milestones entirely in data Communicate with technical precision across matrixed lines to align R&D, commercial, medical, and lab operations functions Strong ownership mindset with the capability to balance scientif…