Associate Director, Media Strategy & Execution

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply. The Opportunity The Associate Director, Media Strategy & Execution will lead the development of integrated media and channel strategies that connect business priorities to measurable patient and healthcare professional engagement. This role will guide how paid, owned, earned, and emerging digital channels work together across the customer journey, ensuring media investment is aligned to brand objectives, audience needs, budget priorities, and performance outcomes. You will partner closely with brand, commercial, web, CRM, content, analytics, IT, legal, privacy, and agency teams to build agile, compliant, data-informed digital journeys for both patients and HCPs. The role requires a strategic operator who can translate insights into actionable media plans, manage investment tradeoffs, strengthen measurement discipline, and continuously optimize the channel ecosystem to improve relevance, efficiency, and business impact. We plan to hire for the AD, Media Strategy and Execution role in September 2026 Responsibilities Develop connected media and channel strategies across paid, owned, earned, CRM, web, search, social, programmatic, video/CTV, endemic, non-endemic, and emerging digital channels, ensuring integration with creative, messaging, audience segmentation, and digital experience design Translate brand objectives, audience insights, market dynamics, and customer needs into clear channel recommendations and journey-led media plans that support awareness, education, diagnosis, treatment consideration, adherence, and ongoing engagement Partner with brand teams to advise on the creation of compelling, compliant, audience-appropriate content while ensuring alignment with regulatory requirements Design and execute KOL and community influencer programs in partnership with brand teams to extend compliant education, engagement, and audience reach. Measure performance using audience engagement and downstream behavior signals to inform optimization and future investment decisions Lead annual, quarterly, and in-cycle media planning processes, including budget allocation, prioritization, and optimization across brands, audiences, channels, and campaign objectives Make data-informed recommendations on channel mix, investment levels, and funding tradeoffs based on business goals, audience opportunity, market conditions, and performance trends Manage media budgets in partnership with brand teams, finance, procurement, agencies, and media operations, ensuring spend is transparent, efficient, compliant, and aligned to approved plans Use performance data, audience quality indicators, reach and frequency, attribution concepts, media mix insights, web analytics, CRM signals, and campaign learnings to identify actionable opportunities Translate complex data into clear insights and recommendations for marketing leaders, brand teams, and cross-functional stakeholders Define success measures, dashboards, reporting inputs, and learning agendas in partnership with analytics and brand stakeholders Champion a test-and-learn culture, including experimentation, personalization pilots, audience refinement, creative testing, channel optimization, an…